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Other possible reactive agents include catalysts which can be used to synthesize various tetracycline compounds of the invention include aluminum, gallium, thallium, silicon, germanium, tin, lead, stilbine, titanium, zirconium, manganese, iron, cobalt, rhodium, nickel, palladium, copper, silver, zinc, mercury, and others (COT, 1560-1616).

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2 , 3 In the absence of appropriate treatment, case-fatality rates in hospitalized children range from 30% to 50%. Breaking the pill may cause too much of the drug to be released at one time.
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